Wegovy 1 mg (Semaglutide)

Wegovy 1 mg is a prescription glucagon-like peptide-1 (GLP-1) receptor agonist pen used as the third step in the standard dose-escalation schedule for chronic weight management. It is indicated for:

• Adults with obesity (BMI ≥30 kg/m²)

• Adults who are overweight (BMI ≥27 kg/m²) with at least one weight-related comorbidity

• Reduction of cardiovascular risk in adults with established cardiovascular disease and BMI ≥27 kg/m²

The 1 mg dose is typically used once weekly during weeks 9–12 of treatment as part of a structured titration protocol.

Key Benefits

• Moderate therapeutic dose supporting continued fat loss progression

• Helps reduce appetite and improve satiety as dosing increases

• Contributes to early clinically meaningful weight reduction during titration (approx. 5–8% body weight by week 12 when combined with lifestyle changes)

• Improves insulin sensitivity as part of GLP-1 activity

• Essential step in building tolerance before reaching maintenance dose (2.4 mg)

• Once-weekly injection with convenient administration

Clinical Importance in Treatment Plan

• Third step in Wegovy dose escalation (after 0.25 mg and 0.5 mg phases)

• Supports gradual adaptation to reduce gastrointestinal side effects

• Foundation phase leading toward maximum therapeutic efficacy

• When continued to full 2.4 mg maintenance dose, semaglutide is associated with up to 15.6% mean body weight reduction in clinical trials (STEP program)

• As part of full regimen, has demonstrated a 20% reduction in major adverse cardiovascular events in high-risk patients (SELECT trial)

Administration

• Administer once weekly via subcutaneous injection

• Injection sites:

  • Abdomen

  • Thigh

  • Upper arm

• Can be taken at any time of day

• With or without meals

• Dose escalation should follow physician guidance

Composition

Each prefilled pen contains:

• Semaglutide: 4 mg in 3 mL (1.34 mg/mL)

Directions for Use

• Use strictly as prescribed by a qualified physician

• Intended for weeks 9–12 in the standard titration schedule

• Do not adjust dose without medical supervision

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