Neuroshima Hex! is a strategy game set in the post-apocalyptic world of Neuroshima, a Polish role-playing game. Each player leads one of four armies: Borgo, Hegemonia (Hegemony), Moloch, and Posterunek (Outpost). Each army deck consists of 34 tiles: soldiers, support tiles, and special actions. You win when all enemy headquarters are destroyed or when your headquarters is the least damaged at the end of the game.

The second edition of Neuroshima Hex!, released at Spiel 2007, had updated graphics and a new, larger board; a special expansion pack sold at the same time included the Neuroshima Hex! Doomsday Machine 1.0, a fifth army that could be used against any of the other ones.